Science
According to a 2019 study, which analyzed data from the National Health and Nutrition Examination Survey (NHANES), approximately 88% of American adults are considered metabolically unhealthy, meaning they exhibit at least one feature of metabolic syndrome, such as high blood pressure, high blood sugar, or excess abdominal fat.
How do Ketones and KETONENRG Work?
The science around the benefits of increasing blood ketones is growing fast. Ketones, specifically in the optimal range of 1.0–2.5 mmol/L, are shown to improve brain function, physical performance, and overall health. You can increase ketone levels by fasting or strenuous exercise. A ketogenic or low-carb diet can also be used to increase blood ketones. KETONENRG provides a simple, efficient way to raise your blood ketones into this effective range, for up to 6 hours without restrictive dieting. Depending on your situation, pairing this supplement with intermittent fasting or a low carb diet may help you enjoy the benefits of ketones more fully and consistently.
Here’s how Ketones Work and What Benefits They Bring:
1. Brainpower and Focus: Your brain is like the engine of your body—it needs lots of energy. Normally, it runs on glucose (sugar), but some brain cells can become insulin resistant and not function as well. Ketones are a cleaner and more efficient fuel that your brain readily uses. Research shows:
- Ketones generate 28% more energy per gram than glucose, meaning your brain is energized better. Not only your brain, but every organ of your body.
- Ketones can supply up to 80% of your brain's energy needs (even when glucose is available), improving focus and mental clarity.
- Ketones help with stress and anxiety by supporting GABA, the brain's calming neurotransmitter.
2. Physical Performance: Athletes use ketones as an additional energy source during exercise. When combined with carbs (duel-fuel), ketones:
- Boost endurance and improve recovery times.
- Stimulate red blood cell production, helping muscles get more oxygen.
- Reduce fatigue and oxidative stress as a clean fuel source.
- Improve cognitive performance which leads to improved physical performance.
3. Metabolic Health and Appetite Control: Ketones help stabilize blood sugar and reduce inflammation, making them beneficial for people with insulin resistance or diabetes. Plus, they naturally suppress hunger by lowering the “hunger hormone,” ghrelin, making it easier to stick to a healthy diet.
4. Longevity and Brain Health: Ketones protect against aging and brain-related conditions:
- They may delay Alzheimer's disease and improve cognitive function.
- Ketones promote brain-derived neurotrophic factor (BDNF), which helps with memory and learning.
- Ketone bodies change brain metabolism where energy from glucose is insufficient or dysfunctional.
- They can also improve recovery after brain injuries and can reduce seizure frequency.
KETONENRG products are built for those who want a clean, consistent source of energy.
(R)-1, 3 butanediol is a natural plant-based ketone precursor derived from non-GMO sugar fermentation that your body fully converts into BHB. This material has gone through many human clinical studies and found to be safe and effective at increasing BHB ketone levels. Some bhb salt vendors claim this material is unsafe, pointing to animal studies where this material was administered in extremely high doses(10X our daily recommendation.) Animal metabolism differs significantly from humans. There are no human studies that support these claims, however it is always prudent to monitor individual responses and consult with healthcare professionals when introducing new supplements or changing your diet.
Here’s how our products work:
- Steady, Long-Lasting Energy: Experience this high-tech Ketone fuel source that delivers consistent energy, and sustains both body and brain. Can elevate BHB levels for up to 6 hours depending on your activity level, fewer hours if exercising heavily.
- Enhanced Cognitive Function: The brain readily uses ketones as fuel, which can improve mental clarity, focus, and concentration. Ketones also help support the production of brain-derived neurotrophic factor (BDNF) which plays a role in memory and cognitive resilience.
- Supports Metabolic Health: Ketones in the blood can help regulate blood sugar and insulin levels by providing an alternative to glucose, which can be especially beneficial for those looking to improve metabolic flexibility or manage weight. Supports intermittent fasting and accelerating transition into ketosis, tapping into your body’s natural fat reserves for energy, promoting a healthy metabolism and steady performance.
- Appetite Control: Ketones may have appetite suppressing effects, helping to reduce hunger and cravings between meals by providing a steady energy source.
- Physical Performance: Ketones provide a readily available fuel source that can enhance performance and support muscle recovery, helping athletes or active individuals maintain stamina and recover faster.
What are the differences between various Ketone Supplements?
D-Betahydroxybutyric Acid (D-BHB): Free Acid or Bio-identical
What it is:D-BHB is the primary ketone naturally produced by your body during ketosis.
Pros:
✔ Can be combined with other ketones to help increase BHB in the blood.Cons:
✘ Pure D-BHB is acidic and difficult to ingest in significant amounts without causing discomfort.Ketone Salts
What they are:D-BHB bound to minerals like sodium, magnesium, or calcium.
Pros:
✔ Simple and affordable.Cons:
✘ Metabolized quickly, leading to short-lived benefits.✘ Difficult to consume enough to see a significant effect.
✘ Many supplements contain both active (D-BHB) and inactive (L-BHB) forms, reducing potency.
Ketone Esters
What they are:Molecules combining D-BHB with precursors like 1,3-Butanediol in an ester bond.
Pros:
✔ Effective at raising blood ketone levels.✔ Used for high-performance tasks and research applications.
Cons:
✘ Expensive to produce, making them less accessible.✘ Can taste unpleasant and may cause gastrointestinal discomfort.
✘ May cause high spikes in blood ketones, which can be suboptimal for sustained performance.
MCT Oil as a Ketone Precursor
What it is:Medium-chain triglycerides (MCTs) are fats that the liver converts into ketones.
Pros:
✔ A natural way to boost ketone production without following a strict ketogenic diet.✔ Can be used alongside other ketone supplements for enhanced effects.
Cons:
✘ Difficult to consume enough to significantly raise BHB levels.✘ Less effective at increasing blood ketones compared to Butanediol.
(R)-1,3-Butanediol as a Ketone Precursor
What it is:A precursor that the body converts fully into D-BHB after ingestion.
Pros:
✔Water soluble and easy to consume in effective, therapeutic amounts.✔Metabolized slowly, providing a stable and prolonged elevation in blood ketone levels (1.0–2.5 mmol/L).
KETONENRG + Electrolytes: Optimized Ketone Support
What makes it unique?KETONENRG + Electrolytes combines (R)-1,3-Butanediol with Ketone Salts, offering both fast-absorbing BHB from salts and long-lasting BHB from (R)-1, 3 Butanediol. The product tastes great!
Why Electrolytes Matter:
Electrolytes are essential for individuals who exercise heavily or follow a low-carb diet, helping maintain hydration and energy.KETONENRG: Ketone Support
What makes it unique?KETONENRG provides 10 grams of (R)-1,3-Butanediol per serving, offering long-lasting elevation of blood ketones, in an application that tastes great!
Studies:
Cognitive Performance Benefits:
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Brain Energy Supply: Ketones can fulfill up to 80% of the brain's energy needs, even when glucose is available.
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Cognitive Enhancement: Supplementing with ketones has been shown to improve cognitive performance by 7%.
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Focus and Calmness: Ketones may enhance focus by increasing the conversion of glutamate to GABA, a neurotransmitter that reduces anxiety and stress.
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Brain Health: A ketogenic diet can increase the number and efficiency of mitochondria (the cell's powerhouses) in the brain, leading to improved energy production.
- Neural Growth: Ketones boost levels of brain-derived neurotrophic factor (BDNF), a protein that supports neuron growth and synaptic connections, enhancing learning and memory.
- Memory Improvement: In animal studies, ketones improved performance in maze tests, indicating enhanced memory and decision-making.
- Post-Exercise Recovery: Ketone supplements can reduce cognitive decline after intense exercise, helping maintain alertness.
- Genetic Conditions: In animal models, ketones enhanced motor coordination, learning, memory, and synaptic plasticity in conditions like Angelman's Syndrome.
Protecting the Brain in Disease and Aging:
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Neuroprotection: Elevated ketone levels may stabilize brain networks by 87%, potentially protecting against cognitive decline and conditions like dementia.
- Bipolar Affective Disorder: Ketogenic Diet led to full remission of the disease and is a promising nutritional model.
- Mental Illness: Significant improvements in refractory mental illness and mood disorders observed when on Ketogenic Diet.
- Brain Metabolism: Ketone bodies on brain metabolism.
- Cognitive Decline: Ketogenic Diet for the Treatment and Prevention of Dementia
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Therapeutic Potential: Ketones, combined with lactate, show promise as a treatment for traumatic brain injury and neurodegenerative diseases.
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Alzheimer's Disease: Low-carbohydrate and MCT-rich ketogenic diets have been associated with cognitive improvements in individuals with Alzheimer's disease.
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Parkinson's Disease: A ketogenic diet improved scores in patients with Parkinson's disease.
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Epilepsy Management: Ketogenic diets may reduce seizure frequency by 40%–90% in individuals with epilepsy.
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Metabolic Disorders: Ketones improved function in children with multiple acyl-CoA dehydrogenase deficiency (MADD), a disorder affecting fatty acid and amino acid oxidation.
Physical Performance and Recovery Benefits:
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Endurance Enhancement: Ketone supplementation improved endurance performance in elite cyclists by 2%.
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High-Intensity Performance: Combining ketones with bicarbonate enhanced high-intensity performance at the end of endurance events without causing gastrointestinal distress.
- Oxygen Delivery: Ketone supplementation increased post-exercise serum erythropoietin (EPO) concentrations, which stimulates red blood cell production, potentially improving muscle oxygenation and performance.
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Overtraining Mitigation: Athletes consuming ketones during a 3-week overtraining period showed improved recovery biomarkers and a 15% increase in power output.
- Protein Synthesis: Adding ketones to a standard post-exercise recovery beverage enhanced the activation of mTORC1, promoting protein synthesis essential for recovery and adaptation.
Metabolic Health and Appetite Control:
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Vascular Health: 1,3-Butanediol, a ketone precursor, reverses age-associated vascular dysfunction, potentially improving blood flow and quality of life in the elderly.
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Inflammation Reduction: 1,3-Butanediol inhibits inflammatory responses and improves outcomes after spinal cord injury.
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Blood Pressure Management: 1,3-Butanediol lowers blood pressure and kidney injury in animal models, suggesting potential benefits for chronic kidney disease.
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Glucose Control: Ketone supplements reduce postprandial (after meal) blood glucose and non-esterified fatty acid levels, indicating usefulness for individuals with insulin resistance or diabetes.
- Appetite Suppression: Ketone supplements lower plasma ghrelin levels (the hunger hormone), reducing perceived hunger and the desire to eat, which may aid in diet adherence and weight management.